A Facile One-Pot Solvent-Free Synthesis of 1,2-Dihydro-1-arylnaphtho [1,2-e] [1,3] oxazine-3-ones Catalyzed by Nano-Fe2O3
نویسندگان: ثبت نشده
چکیده مقاله:
One of the most important goals in medicinal chemistry is the development of new techniques and new heterocyclic compounds with pharmaceutical activity. The present study aimed to use a method for the synthesis of some 1,2-Dihydro-1-arylnaphtho [1,2-e] [1,3] oxazine-3-ones. The question this study tried to answer was this reaction can be performed in present of nano-Fe2O3 as an acid catalyst and solvent-free conditions or not. Therefore, to find answer to the question, some of the1,2-Dihydro-1-arylnaphtho [1,2-e] [1,3] oxazine-3-one derivatives with medicinal properties were synthesized with rapid, high yield, novel, facile, and one-pot condensation of β-naphthol, aromatic aldehydes and urea using by nano-Fe2O3 under solvent-free conditions. The one-pot synthesis on solid inorganic support provides the products in good yields. The synthesized some of oxazine-3-one derivatives has been reported.Nano-Fe2O3 was reused for four runs without significant loss of activity and the effect of the solvents on the model reaction was carried out in various solvents.
منابع مشابه
a facile one-pot solvent-free synthesis of 1,2-dihydro-1-arylnaphtho [1,2-e] [1,3] oxazine-3-ones catalyzed by nano-fe2o3
one of the most important goals in medicinal chemistry is the development of new techniques and new heterocyclic compounds with pharmaceutical activity. the present study aimed to use a method for the synthesis of some 1,2-dihydro-1-arylnaphtho [1,2-e] [1,3] oxazine-3-ones. the question this study tried to answer was this reaction can be performed in present of nano-fe2o3 as an acid catalyst an...
متن کاملNano silica supported ferric chloride as a green and efficient catalyst for one pot synthesis of 1,2-dihydro-1-arylnaphtho[1,2-e][1,3]oxazine-3-ones
An efficient green route for the preparation of naphthoxazinones, applying a three-component one-pot condensation reaction of 2-naphthol, aromatic aldehyde and urea in the presence of nano silica supported ferric chloride under solvent-free conditions has been developed. The present procedure offers several advantages such as short reaction time, simple workup, recovery and reusability of the c...
متن کاملNano silica supported ferric chloride as a green and efficient catalyst for one pot synthesis of 1,2-dihydro-1-arylnaphtho[1,2-e][1,3]oxazine-3-ones
An efficient green route for the preparation of naphthoxazinones, applying a three-component one-pot condensation reaction of 2-naphthol, aromatic aldehyde and urea in the presence of nano silica supported ferric chloride under solvent-free conditions has been developed. The present procedure offers several advantages such as short reaction time, simple workup, recovery and reusability of the c...
متن کاملnano silica supported ferric chloride as a green and efficient catalyst for one pot synthesis of 1,2-dihydro-1-arylnaphtho[1,2-e][1,3]oxazine-3-ones
an efficient green route for the preparation of naphthoxazinones, applying a three-component one-pot condensation reaction of 2-naphthol, aromatic aldehyde and urea in the presence of nano silica supported ferric chloride under solvent-free conditions has been developed. the present procedure offers several advantages such as short reaction time, simple workup, recovery and reusability of the c...
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عنوان ژورنال
دوره 3 شماره 2
صفحات 111- 115
تاریخ انتشار 2014-07-01
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